John Scofield (born December 26, 1951), often referred to as "Sco", is an American jazz-rock guitarist and composer whose playing spans bebop, jazz fusion, funk, blues, soul, and rock.

He has played and collaborated with Miles Davis, Dave Liebman, Joe Henderson, Charles Mingus, Joey DeFrancesco, Herbie Hancock, Pat Metheny, Bill Frisell, Joe Lovano, Pat Martino, Mavis Staples, Phil Lesh, Billy Cobham, Medeski Martin & Wood, George Duke, Jaco Pastorius, John Mayer, Robert Glasper, and Gov't Mule.