George "Buddy" Guy (born July 30, 1936) is an American blues guitarist and singer. He is an exponent of Chicago blues and has influenced guitarists including Jimi Hendrix, Eric Clapton, Jimmy Page, Keith Richards, Jeff Beck, John Mayer and Stevie Ray Vaughan. In the 1960s, Guy played with Muddy Waters as a house guitarist at Chess Records and began a musical partnership with the harmonica player Junior Wells.

Guy was ranked 30th in Rolling Stone magazine's 100 Greatest Guitarists of All Time. His song "Stone Crazy" was ranked 78th in Rolling Stone's list of the 100 Greatest Guitar Songs of All Time. Clapton once described him as "the best guitar player alive".

In 1999 Guy wrote the book, Damn Right I've Got the Blues, with Donald Wilcock.

Guy's autobiography, When I Left Home: My Story, was published in 2012.